Allophenic Mice: A Pillar Awaiting Its Superstructure

Allophenic mice: a pillar awaiting its superstructure.

Allophenic mice in cleft-palate investigations.

T1Wh (Rb (5;19)1Wh), an albino strain of mice not previously used in the investigation of cleft palate (CP), is homozygous for a (5;19) Robertsonian translocation which provides conspicuous chromosomal markers. Preliminary studies in this laboratory revealed that CP is induced in all the offspring of T1Wh females treated with 2.5 mg of cortisone acetate on days 11-14 of pregnancy and that palat...

A Unified Superstructure for UML

A key aspect of successfully using UML is understanding the semantics of the notations. UML 2 will increase the already substantial collection of notations supported by UML 1.x. At the same time, this will augment the difficulty users experience in understanding semantics. In this paper we propose that while the diverse notations may render concepts differently, the concepts can often be consid...

Genetic differences in red cell osmotic fragility: analysis in allophenic mice.

Mice of strain DBA/2J were found to produce red cells considerably more resistant to osmotic lysis than cells from C57BL/6J or the F1 hybrid between the two strains. Such strain-specific differences in osmotic fragility could be the result of genetically determined humoral or other systemic differences that indirectly influence red cell properties. Alternatively, this phenotypic variation might...

Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice

We have studied contributions to hematopoiesis of genetically distinct stem cell populations in allophenic mice. Chimeras were made by aggregating embryos of inbred strains known to differ with respect to stem cell population kinetics. One partner strain (DBA/2) has previously been shown to normally have a stem cell (CFU-S) population of which 24% are in S-phase of the cell cycle, whereas the h...